Zombified (senescent) cells contribute to aging; therapies aim to boost immune clearance
They publishedZombified cells may drive aging, and scientists are devising new ways to get rid of them
First reportLive Science · 7 Oct, 10:00Z
Latest reportLive Science · 7 Oct, 10:00Z
Span0 hours · two reports
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Why it matters
What
Emerging therapies target senescent “zombie” cells by killing them or helping macrophages clear them from aging tissues.
Why
These cells inflame tissues, while senolytics, EP2 blockade, and improved macrophage energy have improved aging-related outcomes in studies.
Watch
Researchers will assess whether these approaches safely reverse aging signs and reduce age-related disease risk in people.
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Summary
- Emerging treatments seek to reverse aging signs and reduce age-related disease risk.
- Zombie cells are senescent cells that refuse to die and inflame tissues.
- Senolytics drugs can kill senescent cells, lowering inflammation and improving function in mice.
- EP2 receptor on macrophages impairs clearance of senescent cells as we age.
- Blocking EP2 or boosting macrophage energy improves aging-related outcomes in studies.