Mpox continues to circulate in the United States and may become endemic.
They published'Mpox has not disappeared': Why the infectious disease is still spreading in the US and may be here to stay
First reportLive Science · 6 Oct, 10:00Z
Latest reportLive Science · 6 Oct, 10:00Z
Span0 hours · two reports
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Why it matters
What
Mpox cases declined after the 2022 surge but continue circulating in the United States, with thousands recorded in 2024 and 2025.
Why
Persistent transmission, limited vaccination, and waning public health efforts may allow mpox to become endemic.
Watch
Monitor case trends, vaccination coverage, and whether renewed public health measures can reduce or eliminate transmission.
Where the coverage comes from
Perspective mix: 1 center.
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How it unfolded — every article
Summary
- Mpox outbreaks surged in 2022, then declined but did not disappear in the US.
- A August report recorded 2,800 cases in 2024 and over 2,500 in 2025.
- Most samples stem from the 2022 outbreak strain, indicating persistence of transmission.
- Experts attribute continued spread to insufficient vaccination and other factors.
- Public health efforts have waned, risking elimination of mpox in the US.