{"id":"2ad7bd1c-1745-4a20-9cfd-809adde30941","url":"https://www.futurity.org/ovarian-cancer-chemotherapy-3339352/","domain":"futurity.org","outlet":{"name":"Futurity","country":null,"cred":null,"lean":null,"curated":false},"title":"Team finds way to reverse ovarian cancer's chemo resistance","plainHeadline":null,"rewrite":{"model":null,"at":null},"summary":["1. Researchers identified how ovarian cancer cells resist chemotherapy, specifically cisplatin.","2. Cisplatin damages cancer cells' DNA and disrupts microtubules for survival.","3. Higher levels of TPPP3 protein help cancer cells withstand chemotherapy effects.","4. Patients with lower TPPP3 levels lived longer and responded better to treatment.","5. Removing TPPP3 restored sensitivity to cisplatin in laboratory models.","6. The study shifts focus from DNA damage to cancer cell structure.","7. Researchers aim to develop drugs targeting TPPP3 and identify at-risk patients.","8. Findings may improve chemotherapy effectiveness and personalize treatments."],"topics":["Health"],"lang":"eng","publishedAt":"2026-06-25T18:35:55.000Z","ingestedAt":"2026-06-25T18:48:27.396Z","story":null}